Stoke Therapeutics Inc

Stoke Therapeutics Inc. an early-stage biopharmaceutical company develops medicines to treat the underlying causes of severe genetic diseases in the United States. The company utilizes its proprietary targeted augmentation of nuclear gene output to develop antisense oligonucleotides to selectively restore protein levels. Its lead clinical candidate is STK-002 which is in preclinical stage for the treatment of autosomal dominant optic atrophy. The company is also developing STK-001 which is in phase I/II clinical trial to treat Dravet syndrome; and programs focused on multiple targets including haploinsufficiency diseases of the central nervous system and eye. It had entered into a license and collaboration agreement with Acadia Pharmaceuticals Inc. for the discovery development and commercialization of novel RNA-based medicines for the treatment of severe and rare genetic neurodevelopmental diseases of the central nervous system. The company was formerly known as ASOthera Pharmaceuticals Inc. and changed its name to Stoke Therapeutics Inc. in May 2016. Stoke Therapeutics Inc. was incorporated in 2014 and is based in Bedford Massachusetts.